Putting the heaviest weight up front and lightest weight in the back shifts the center of mass of the clubhead toward the front and you get the lowest spin possible for that head.

Putting the heaviest weight in the back and lightest in the front moves the center of mass back and gives you the highest spin possible with that club.

So, if the two weights are the same, the center of mass will be as centered as it can get for the TSR4 and the spin will be in the middle of the two most extreme values.

A lot of it will depend on which weights you are using compared to the stock weights. If they are both significantly lighter than the stock front weight for example, that will move the COG towards the front even more than the normal configuration, lowering MOI, decreasing forgiveness and lowering ball flight and spin.